منابع مشابه
Rewriting the Epigenome
The eukaryotic genome is packaged into a highly ordered chromatin structure, with specific domains regulating the transcription patterns of local genes. Hathaway et al. now present a breakthrough technique in the artificial induction of chromatin marks and use this experimental model to test the properties of an induced heterochromatic domain.
متن کاملThe Aging Epigenome.
During aging, the mechanisms that normally maintain health and stress resistance strikingly decline, resulting in decrepitude, frailty, and ultimately death. Exactly when and how this decline occurs is unknown. Changes in transcriptional networks and chromatin state lie at the heart of age-dependent decline. These epigenomic changes are not only observed during aging but also profoundly affect ...
متن کاملchroGPS: visualizing the epigenome
The chroGPS package provides tools to generate intuitive maps to visualize the association between genetic elements, with emphasis on epigenetics. The approach is based on Multi-Dimensional Scaling. We provide several sensible distance metrics, and adjustment procedures to remove systematic biases typically observed when merging data obtained under different technologies or genetic backgrounds....
متن کاملEpigenetics of the epigenome.
Jeff is the Doris and Normal Giles Professor of Molecular Biology and Functional Genomics in the Department of Genetics at the University of Georgia. He is also a Georgia Research Alliance Eminent Scholar and department head in Genetics. His research has focused on plant genome structure and evolution for more than 30 years, particularly the involvement of transposable elements in the growth an...
متن کاملThe evolving epigenome.
Epigenetic studies include the investigation of DNA methylation, histone modifications, chromatin remodeling and gene regulation by noncoding RNAs (ncRNAs). Epigenetic alterations are critical for early developmental processes, the silencing of the inactive X-chromosome and tissue-specific gene regulation. A comprehensive picture of epigenetic patterns in normal cells is now emerging; these pat...
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ژورنال
عنوان ژورنال: Nature
سال: 2015
ISSN: 0028-0836,1476-4687
DOI: 10.1038/518313a